direction of secretory vesicles to the cell membrane either secreted to the extracellular environment or added to the PM. STEPS: budding – tethering – docking – priming (neurons) – fusion (response to calcium elevation)
cellular eating for large solid particles (bacteria or cellular debris). Particle binds to receptor leads to actin cytoskeleton rearrangements which forms a phagosome which fuses with lysosome (phagolysosome) digested
molecular switches: off when GDP bound, on when GTP bound. NO PHOSPHORYLATION the guanine-nucleotide exchange factor (GEF) exchanges the GDP by a GTP to turn on, and its turned off by a GAP (liberation of a Pi)
consitutive continuous and not regulated stream of vesicles with lipids and proteins for extracellular matric or PM. Regulated for proteins that are stored and secreted on demand